GHK-cu 5 mg

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Overall Health Benefits of GHK-Cu

  • Tightens loose skin [1-3]
  • Enhances skin elasticity [4-7]
  • Reduces fine lines and wrinkles [8-12]
  • Reverses thinning of aging skin [13-17]
  • Evens out skin texture [1, 3, 4, 8]
  • Prevents aging through its antioxidant effects [1, 13-16]
  • Accelerates wound healing [1, 6, 17-50]
  • Improves lung health [51-54]
  • Fights hair loss [55-59]
  • Fights different cancer types [60-63]
  • Accelerates nerve regeneration [64-67]
  • Fights anxiety [68-71]
  • Combats cognitive dysfunction [72-83]
  • Protects the liver [84-87]
  • Promotes bone repair [1, 88-89]
  • Fights Inflammation [90-91]

What is GHK-Cu?

GHK-Cu, also known as copper peptide GHK-Cu or copper tripeptide-1, is a naturally occurring peptide composed of the amino acids glycine, histidine, and lysine, with a copper ion attached. It is derived from a larger protein called thymosin beta-4. GHK-Cu has gained attention in the field of skincare and regenerative medicine due to its potential biological activities and therapeutic effects.

GHK-Cu is known for its role in wound healing, tissue repair, and regeneration. It has been found to promote Synthesis of collagen, enhance antioxidant activity, stimulate blood vessel growth and formation, and improve the overall health of the skin. These properties make ghk-cu a popular ingredient in skincare and cosmetic products now, particularly those targeting anti-aging, skin rejuvenation, and scar reduction.

In addition to its effects on the skin, GHK-Cu has also demonstrated various other biological activities. It has been shown to possess anti-inflammatory properties, modulate immune responses, and promote the synthesis of important molecules like DNA and proteins. Copper Peptide GHK-Cu has also been studied for its potential in hair growth stimulation and as a treatment for certain neurological disorders.

Research on GHK-Cu is ongoing, and its full range of effects and mechanisms of action are still being explored. However, the existing scientific evidence suggests that GHK-Cu has promising therapeutic potential in multiple areas, including skincare, wound healing, and regenerative medicine.

It’s worth noting that GHK-Cu is primarily used in topical formulations and cosmetic products for skincare and cosmetic purposes. Before using any cosmetic products, containing GHK-Cu or considering cosmetic products for its potential therapeutic benefits, it is advisable to consult with a healthcare professional or dermatologist for personalized advice and guidance.

How GHK-Cu Works?

GHK-Cu, also known as copper peptide GHK-Cu or copper tripeptide-1, exerts its biological effects through various mechanisms of action. Here are some of the key ways in which GHK-Cu is believed to work:

  • Stimulation of Collagen Production:

    GHK-Cu has been found to stimulate the synthesis of collagen, a crucial protein that provides structure, strength, and elasticity to the skin. Synthesis of collagen tends to decrease with age, leading to the appearance of wrinkles and sagging skin. By promoting collagen synthesis, GHK-Cu helps improve the skin’s texture, firmness, and overall appearance.

  • Antioxidant Activity:

    GHK-Cu possesses antioxidant properties, which means it helps protect cells from oxidative stress and damage caused by free radicals. By scavenging free radicals and reducing oxidative damage, GHK-Cu contributes to the overall health and vitality of the skin.

  • Stimulation of Wound Healing:

    GHK-Cu has been extensively studied for its wound healing properties. It promotes the migration of various cells involved in wound healing, such as fibroblasts and keratinocytes, leading to faster tissue repair. GHK-Cu also supports the formation of new blood vessels, a process known as angiogenesis, which is crucial for delivering oxygen and nutrients to the healing tissues.

  • Modulation of Inflammation:

    GHK-Cu has been found to possess anti-inflammatory properties. It can help regulate the inflammatory response in the skin and reduce the production of pro-inflammatory molecules. By mitigating inflammation, GHK-Cu contributes to a calmer and healthier skin environment.

  • Enhancement of Copper Function:

    Copper is an essential trace element involved in various physiological processes. GHK-Cu delivers a copper ion to the cells, helping to restore and maintain optimal copper levels. Copper plays a vital role in collagen synthesis, antioxidant defense, and other cellular functions, and GHK-Cu ensures an adequate supply of copper for these processes.

  • Cell Signaling and Gene Expression:

    GHK-Cu has been shown to interact with specific cell receptors and signaling pathways, influencing gene expression and cellular functions. It can regulate the expression of genes involved in collagen synthesis, antioxidant activity, and other biological processes, thereby promoting cellular rejuvenation and repair.

It’s important to note that while the above mechanisms have been observed in various studies, the exact details of how GHK-Cu works at a molecular level are still being explored. Furthermore, the effectiveness and specific applications of GHK-Cu may vary depending on the formulation, concentration, and mode of delivery (topical or injectable).

Chemical Structure of GHK-Cu

IMG

Benefits of GHK-Cu

Tighten loose skin

Loose skin is a common concern as we age or undergo weight loss. Fortunately, there’s a promising solution to restore skin firmness and achieve a more youthful appearance – human tri peptide GHK-Cu, also known as copper peptide GHK-Cu. In this article, we will explore the skin care benefits of human tripeptide GHK-Cu and how it can help tightens loose skin effectively.

Stimulates Collagen and Elastin Production:

GHK-Cu has been extensively studied for its ability to stimulate the synthesis of collagen and elastin, two crucial proteins responsible for skin elasticity and firmness. By promoting collagen and elastin production, GHK-Cu helps to tightens loose skin, reducing sagging and improving overall skin firmness, texture, and tone. This peptide has shown remarkable results in multiple studies, making it a highly effective option for those seeking to address loose skin concerns.

Boosts Skin Regeneration:

One of the remarkable properties of GHK-Cu is its ability to enhance skin rejuvenation. It promotes the proliferation of skin cells, including fibroblasts and keratinocytes, which are essential for wound healing and tissue repair. By stimulating cell turnover, GHK-Cu helps to rejuvenate the skin and improve its tightness and resilience.

Improves Skin Thickness and Density:

Studies have shown that GHK-Cu can increase skin thickness and skin density, which are important factors for tightening loose skin. By enhancing the structural integrity of the skin, GHK-Cu contributes to a more youthful and toned skin appearance throughout.

Enhances Skin Hydration:

Proper hydration is vital for maintaining healthy and plump skin. GHK-Cu has been found to improve skin hydration by promoting the synthesis of hyaluronic acid, a natural moisturizing substance that helps the skin retain water. By enhancing skin hydration, GHK-Cu contributes to the overall firmness and smoothness of the skin.

Supports Skin Healing and Repair:

In addition to its tightening effects, GHK-Cu has potent wound healing properties. It accelerates the healing process by promoting the migration of immune cells involved in tissue repair and stimulating the formation of new blood vessels. This enhanced healing response can help tighten loose skin and improve its overall quality.

When it comes to tightening loose skin and rejuvenating your skin appearance, GHK-Cu is a standout ingredient. Through its ability to stimulate collagen and elastin production, promote skin regeneration, improve skin thickness and even skin density further, enhance hydration, and support healing and repair processes tighten loose skin, GHK-Cu offers a comprehensive approach to addressing loose skin concerns. tighten loose skin.

Enhances skin elasticity

Maintaining skin elasticity is crucial for a youthful, vibrant skin appearance. As we age, our skin tends to lose its elasticity, leading to sagging and the formation of fine lines and wrinkles. However, GHK-Cu, also known as copper peptide GHK cu, has emerged as a powerful ingredient in skincare formulations that can help enhance skin elasticity. In this article, we will explore how copper peptide GHK cu works to improve skin elasticity, helping you achieve firmer and more resilient skin.

Stimulates Collagen and Elastin Production:

GHK-Cu has been extensively studied for its ability to stimulate the synthesis of collagen and elastin, two proteins that play a vital role in maintaining skin firmness and elasticity. Collagen provides structural support, while elastin allows the skin to stretch and bounce back. By promoting the production of these proteins, GHK-Cu helps to enhance skin elasticity and skin firmness both.

Supports Skin Regeneration:

One of the remarkable properties of GHK-Cu is its capacity to support skin regeneration. It facilitates the proliferation of skin cells, including skin fibroblasts, which are responsible for producing collagen and elastin. This increased cell turnover helps in improving skin elasticity and reducing the appearance of fine lines and wrinkles.

Protects Against Collagen Breakdown:

GHK-Cu has shown promising anti-aging effects by protecting against collagen degradation. It helps inhibit the activity of enzymes that break down collagen fibers, such as matrix metalloproteinases (MMPs). By preventing collagen breakdown, GHK-Cu helps maintain the structural integrity of the skin, enhancing its elasticity.

Promotes Skin Hydration:

Proper hydration is essential for maintaining skin elasticity. GHK-Cu has been found to promote skin hydration by boosting the production of hyaluronic acid, a natural moisturizing substance that helps retain water in the skin. Improved hydration levels contribute to enhanced skin elasticity, giving it a plump and supple appearance.

Increases Skin Thickness and Density:

Studies have indicated that GHK-Cu can increase the skin density, thickness and, which are important factors for both skin density improved elasticity. It helps to reinforce the skin’s barrier function and strengthen the skin density extracellular matrix, resulting in firmer and more elastic skin.

GHK-Cu has gained recognition as a valuable ingredient for enhancing skin elasticity. By stimulating collagen and elastin production, supporting skin regeneration, protecting against collagen breakdown, promoting skin hydration, and increasing skin thickness and skin density throughout, GHK-Cu offers a comprehensive approach to improve skin elasticity and combat the signs of aging.

Reduces fine lines and wrinkles

Fine lines and wrinkles and rough skin are common signs of aging that can make us feel self-conscious about our own skin appearance. Fortunately, there is a powerful ally in the battle against these visible signs of aging: GHK-Cu, also known as copper peptide GHK-Cu. GHK-Cu has gained recognition in the skincare industry for its remarkable ability to reduce fine lines and wrinkles and rough skin. In this article, we will explore how GHK-Cu works to rejuvenate the skin, helping you achieve a smoother, more youthful complexion.

Stimulates Collagen Synthesis:

Collagen is a key structural protein responsible for maintaining skin’s firmness and elasticity. GHK-Cu has been found to stimulate collagen synthesis, encouraging the production of new collagen fibers in the skin. This helps to plump up the skin, reducing the appearance of fine lines and wrinkles.

Boosts Skin Regeneration:

GHK-Cu has potent regenerative properties that promote the renewal of skin cells. It activates various cellular processes involved in skin regeneration, including the proliferation of skin fibroblasts in, which are responsible for producing collagen and elastin. This cellular rejuvenation helps to diminish the depth and visibility of wrinkles.

Increases Skin Thickness and Density:

With age, the skin becomes thinner skin smoother and less dense, contributing to the formation of wrinkles. GHK-Cu has been shown to increase skin thickness and skin density, by stimulating the synthesis of key components in the skin density extracellular matrix. This results in more skin density, plumper skin smoother and more resilient skin, reducing the appearance of fine lines and wrinkles in aged skin.

Enhances Skin Elasticity:

Loss of skin elasticity is a major contributor to the development of wrinkles. GHK-Cu helps to enhance skin elasticity by promoting the production of elastin, a protein responsible for maintaining the skin’s ability to stretch and recoil. By improving skin elasticity, GHK-Cu helps to smooth out wrinkles and restore a more youthful skin appearance throughout.

Protects Against Oxidative Stress:

Oxidative stress can accelerate skin aging and the formation of wrinkles. GHK-Cu possesses powerful antioxidant properties, protecting the skin from oxidative damage caused by free radicals. By reducing oxidative stress, GHK-Cu helps to prevent the formation of new wrinkles and minimize the appearance of existing ones.

GHK-Cu offers a multifaceted approach to reducing fine lines and wrinkles, making it an excellent addition to any anti-aging skincare regimen. By stimulating collagen synthesis, boosting skin regeneration, increasing skin thickness and density, enhancing skin elasticity, and protecting against oxidative stress, GHK-Cu helps to restore a smoother, more youthful complexion..

Reverses thinning of aged skin

As we age, our skin undergoes various changes, including thinning, which can make the skin spots on it more vulnerable to damage and result in a lack of youthful fullness. Thankfully, there is a powerful ally in the fight against thinning aging skin: GHK-Cu, also known as copper peptide GHK-Cu. GHK-Cu has garnered attention in the skincare industry for its remarkable ability to reverse the thinning of aged skin. In this article, we will explore how GHK-Cu works to restore thickness to the aging skin, helping you regain a more vibrant and resilient complexion.

Promotes Collagen and Elastin Synthesis:

Collagen and elastin are essential proteins responsible for maintaining the structure and elasticity of the skin. GHK-Cu has been found to promote the synthesis of collagen and elastin, helping to restore the skin’s support system. This leads to rough skin with increased thickness and density, effectively reversing the thinning associated with aging.

Enhances Dermal Matrix Formation:

GHK-Cu stimulates the production of important components in the dermal matrix, such as glycosaminoglycans and proteoglycans. These substances play a vital role in maintaining skin hydration and supporting the structure of the skin. By enhancing dermal matrix formation, GHK-Cu helps to restore the thickness and volume of aged skin.

Improves Blood Vessel Formation:

Thinning often experiences reduced blood flow, which can further contribute to its frailty. GHK-Cu has been shown to enhance the formation of new blood vessels, a process known as angiogenesis. By improving blood circulation in the aging skin, GHK-Cu promotes nutrient delivery and oxygenation, supporting the rejuvenation and thickening of aged skin.

Activates Stem Cells:

Stem cells are crucial for maintaining the regenerative capacity of the skin. GHK-Cu has the remarkable ability to activate dormant stem cells, stimulating their proliferation and differentiation. This rejuvenates the skin and aids in the regeneration of healthy, thicker tissue, reversing the thinning associated with aging skin.

Protects Against Matrix Metalloproteinases (MMPs):

Matrix metalloproteinases (MMPs) are enzymes that break down collagen and elastin in the skin, contributing to thinning and aging. GHK-Cu has been found to inhibit MMP activity, preventing the excessive degradation of these important proteins. This protective effect helps to maintain the thickness and integrity of the skin.

GHK-Cu offers a promising solution for reversing the thinning of aged skin. By promoting collagen and elastin synthesis, enhancing dermal matrix formation, improving blood vessel formation, activating stem cells, and protecting against MMPs, GHK-Cu helps to restore thickness and vitality to the aged skin.

Evens out skin texture

Achieving a flawless and even skin texture is a common goal for many individuals. If you’re looking for a solution to address uneven skin texture, look no further than GHK-Cu, also known as copper peptide GHK-Cu. GHK-Cu has gained significant attention in the skincare world for its ability to improve and even out skin texture. In this article, we will explore how-Cu works to promote a smoother and more refined complexion, helping you unlock your skin’s true radiance.

Exfoliation and Cell Renewal:

GHK-Cu stimulates the process of exfoliation, helping to remove dead skin cells and promote cell turnover. By gently sloughing off the outer layer of the skin, GHK-Cu encourages the growth of fresh, new cells. This exfoliating effect contributes to a smoother skin texture, reducing the appearance of roughness and unevenness.

Regulation of Extracellular Matrix Remodeling:

The extracellular matrix (ECM) is responsible for maintaining the structure and integrity of the skin. GHK-Cu has been found to regulate ECM remodeling by promoting the synthesis of important components such as collagen, elastin, and glycosaminoglycans. This regulation helps to restore balance to the skin, resulting in improved texture and a more even complexion.

Anti-inflammatory Effects:

Inflammation of skin spots can contribute to various rough skin and issues with skin spots, including uneven texture. GHK-Cu possesses potent anti-inflammatory properties, which help to calm and soothe the various rough skin and spots within. By reducing the skin spots and inflammation, GHK-Cu aids in minimizing redness, irritation, and unevenness of rough skin spots, resulting in a smoother and more uniform skin surface.

Enhanced Moisture Retention:

Skin dehydration can exacerbate uneven texture, making the skin appear rough and lackluster. GHK-Cu has been shown to enhance the skin’s ability to retain moisture by improving the function of the skin barrier. This increased hydration helps to plump and smooth the skin, resulting in an improved texture and a more youthful appearance than normal skin.

Regulation of Enzymes and Growth Factors:

GHK-Cu has a regulatory effect on various enzymes and growth factors involved in skin health and repair. It can modulate the activity of enzymes that affect skin texture, such as matrix metalloproteinases (MMPs), which are responsible for degrading collagen and elastin. Additionally, GHK-Cu promotes the production of growth factors that contribute to skin rejuvenation and rejuvenation, leading to a smoother and more even skin texture.

Conclusion:

GHK-Cu is a remarkable ingredient that can help you achieve a more even and refined skin texture. Through its exfoliating and cell renewal properties, regulation of ECM remodeling, anti-inflammatory effects, enhanced moisture retention, and regulation of enzymes and growth factors, GHK-Cu works to transform the skin’s texture, unveiling a smoother and more radiant complexion.

Consider incorporating skincare products or treatments that contain GHK-Cu to experience its incredible benefits. Consult with skincare professionals to find products with optimal concentrations of GHK-Cu and receive personalized recommendations tailored to your specific skincare needs.

Prevents aging through its antioxidant effects

Aging is a natural process that affects us all, aging and cosmetic products but with advancements in skincare, we can slow down its visible effects. GHK-Cu, also known as copper peptide GHK-Cu, has emerged as a potent ally in the battle against both aging and cosmetic products. Its remarkable antioxidant effects have captured the attention of skincare enthusiasts and professionals alike. In this article, we will explore how GHK-Cu helps prevent aging and cosmetic products by combating oxidative stress and promoting youthful-looking skin.

Neutralizing Free Radicals:

One of the primary mechanisms through which GHK-Cu prevents aging is by neutralizing free radicals. Free radicals are highly reactive molecules that can cause oxidative damage to cells, leading to premature aging. GHK-Cu acts as a powerful antioxidant, scavenging these harmful free radicals and protecting the skin from oxidative stress .

Boosting Collagen and Elastin Production:

Collagen and elastin are essential proteins responsible for maintaining the skin’s elasticity and. However, their production naturally declines with age. GHK-Cu has been shown to stimulate the synthesis of collagen and elastin, helping to restore and maintain the skin’s youthful structure. This effect contributes to smoother, firmer skin and a reduction in the visible signs of aging, such as wrinkles and sagging.

Enhancing Skin Repair and Regeneration:

As we age, the skin’s ability to repair and regenerate itself diminishes. GHK-Cu has been found to promote normal skin and repair processes in human body by activating various growth factors and signaling pathways in normal skin. It aids in the rejuvenation of damaged and aged skin cells and supports the formation of new, healthy cells aged skin repairs. By enhancing skin repair and regeneration, GHK-Cu helps the human body to maintain a more youthful skin appearance throughout.

Anti-inflammatory Properties:

Chronic skin inflammation that is closely linked to the aging process and can contribute to the breakdown of collagen and elastin. GHK-Cu exhibits anti-inflammatory properties, reducing in the least skin inflammation. By calming the skin and minimizing inflammatory responses, GHK-Cu helps to prevent premature aging and maintain a healthier complexion.

Protection against Environmental Damage:

Environmental factors, such as UV radiation and pollution, can accelerate aging and cause oxidative stress on the skin. GHK-Cu acts as a shield against environmental damage by neutralizing free radicals and reinforcing the skin’s natural defense mechanisms. It helps to preserve the skin’s integrity, preventing premature signs of aging caused by external aggressors.

GHK-Cu is a remarkable ingredient that plays a pivotal role in preventing aging through its potent antioxidant effects. By neutralizing free radicals, boosting collagen and elastin production, enhancing skin repair and regeneration, exhibiting anti-inflammatory properties, and protecting against environmental damage, GHK-Cu empowers you to maintain a youthful and radiant complexion.

Accelerates Wound Healing

Wound healing is a complex biological process that involves multiple stages of tissue repair. Scar tissue formation can impede proper healing and affect the cosmetic appearance of the skin. However, GHK-Cu peptide, also known as copper peptide GHK-Cu, has shown promising potential in accelerating wound healing and promoting the repair of scar tissue. In this article, we will delve into the benefits of GHK-Cu copper peptide in accelerating wound healing and facilitating scar tissue repair.

Stimulation of Collagen Production:

GHK-Cu peptide has been found to stimulate the synthesis of collagen, a crucial protein that provides structural support to the skin and plays a key role in wound healing. Collagen helps strengthen the wound site, promotes the formation of new blood vessels, and supports the growth of new skin cells. By enhancing collagen production, GHK-Cu peptide facilitates the regeneration of healthy skin tissue, leading to faster wound healing.

Promotion of Cell Migration and Proliferation:

GHK-Cu peptide has been shown to enhance the migration of various types of skin cells, including fibroblasts and keratinocytes, to the site of the wound. These cells are essential for wound closure and tissue regeneration. GHK-Cu peptide also promotes cell proliferation, allowing for faster replacement of damaged or dead cells with new, healthy cells. This cellular activity facilitated by GHK-Cu peptide accelerates wound healing and helps accelerate the healing process.

Anti-inflammatory Effects:

Inflammation is a natural response to injury, but excessive or prolonged inflammation can delay wound healing. GHK-Cu peptide possesses anti-inflammatory properties and has been shown to modulate the inflammatory response in wounds. By reducing skin inflammation, GHK-Cu peptide helps create a more favorable environment for wound healing and minimizes the risk of complications.

Stimulation of Angiogenesis:

GHK-Cu peptide has been found to promote angiogenesis, blood vessel growth or the formation of new blood vessels, in the vicinity of the wound. Adequate blood supply is vital for delivering oxygen and nutrients to the healing site, supporting cell growth, and facilitating tissue repair. By stimulating angiogenesis, or blood vessel growth, GHK-Cu peptide enhances the vascularization of the wound area, and blood vessel growth enabling more efficient wound healing.

GHK-Cu peptide has demonstrated remarkable potential in accelerating wound healing and facilitating scar tissue repair. Its ability to stimulate collagen production, promote cell migration and proliferation, exert anti-inflammatory effects, and stimulate angiogenesis contributes to its efficacy in wound healing applications. Incorporating GHK-Cu peptide into wound care regimens may lead to faster healing, reduced scar formation, and improved outcomes for individuals with various types of wounds.

Improves Lung Health

Maintaining optimal lung health is essential for overall well-being and quality of life. Emerging research suggests that GHK-Cu peptide, also known as copper peptide GHK-Cu, may play a beneficial role in improving lung health. In this article, we will explore the potential benefits of human peptide GHK-Cu in enhancing lung function and supporting respiratory well-being.

Anti-inflammatory Properties:

GHK-Cu peptide has demonstrated potent anti-inflammatory effects, which may be beneficial for lung health. Inflammation plays a central role in various respiratory conditions, such as chronic obstructive pulmonary disease (COPD), asthma, and acute respiratory distress syndrome (ARDS). By reducing inflammation in the lungs, GHK-Cu peptide may help alleviate symptoms and promote healing in these conditions.

Protection Against Oxidative Stress:

Oxidative stress, characterized by an imbalance between the production of reactive oxygen species (ROS) and the human body’s antioxidant defenses, can contribute to lung damage and impair respiratory function. GHK-Cu peptide has been shown to possess antioxidant properties, protecting cells from oxidative damage and promoting a healthy tissue redox balance. By neutralizing ROS and reducing oxidative stress, GHK-Cu may help preserve lung tissue integrity and function.

Stimulation of Tissue Repair and Regeneration:

GHK-Cu peptide has been found to promote tissue repair and regeneration in various organs, including the lungs. It stimulates the production of extracellular matrix components, such as collagen and elastin, which are vital for maintaining the structural integrity of lung tissue. GHK-Cu peptide also enhances the migration and proliferation of lung cells, aiding in the regeneration of damaged or injured lung tissue.

Modulation of Fibrosis:

Pulmonary fibrosis, characterized by the excessive accumulation of scar tissue in the lungs, can lead to impaired lung function. GHK-Cu peptide has shown promising effects in modulating fibrosis by inhibiting the activity of transforming growth factor-beta (TGF-β), a key regulator of fibrotic processes [4]. By mitigating fibrotic responses, GHK-Cu may help prevent or reduce lung fibrosis, thereby preserving lung function.

GHK-Cu holds potential in improving lung health through its anti-inflammatory, antioxidant, healthy tissue, repair, and fibrosis-modulating properties. By reducing inflammation, protecting against oxidative stress, promoting healthy tissue repair and regeneration, and modulating fibrotic processes, GHK-Cu may contribute to enhanced lung function and respiratory well-being. Further research is needed to fully understand the mechanisms and clinical implications of GHK-Cu in lung health.

Fights Hair Loss

Hair loss is a common concern for many individuals, and the search for effective solutions continues. GHK-Cu peptide, also known as copper peptide GHK-Cu, has gained attention for its potential to promote hair growth and combat hair loss. In this article, we will explore the benefits of copper peptide GHK-Cu in revitalizing hair growth and addressing hair loss concerns.

Stimulates Hair Follicle Activity:

GHK-Cu has been shown to stimulate the activity of hair follicles, the tiny structures responsible for the hair follicles growth. It promotes the proliferation of dermal papilla cells, which play a crucial role in hair follicle development and maintenance. By enhancing the activity of hair follicles, GHK-Cu can support the growth of healthy and strong hair follicles.

Enhances Microcirculation in the Scalp:

Healthy hair growth relies on proper blood flow and nutrient supply to the hair follicles. GHK-Cu has been found to enhance microcirculation in the scalp, leading to improved nutrient delivery to the hair follicles. This increased blood flow can help nourish the hair follicles, promote hair growth, and prevent hair loss.

Supports Collagen and Elastin Production:

Collagen and elastin are essential components of the scalp and hair structure. GHK-Cu has been shown to stimulate the production of collagen and elastin, which contribute to the strength, elasticity, and overall health of the skin and hair products. By supporting the synthesis of these proteins, GHK-Cu can help improve hair quality and resilience.

Anti-inflammatory and Antioxidant Effects:

Inflammation and oxidative stress can disrupt the hair follicle size growth cycle and contribute to the hair follicle size loss. GHK-Cu exhibits anti-inflammatory properties and acts as an antioxidant, protecting the hair follicles from damage caused by free radicals. By reducing skin inflammation and oxidative stress, GHK-Cu can create a favorable environment for healthy hair follicle size and growth.

GHK-Cu peptide shows promising potential in promoting the hair follicles growth and addressing hair loss concerns. By stimulating hair follicle activity, enhancing scalp microcirculation, supporting collagen and elastin production, and exerting anti-inflammatory and antioxidant effects, GHK-Cu offers a multifaceted approach to revitalizing hair growth. Further research is needed to fully understand the mechanisms and optimal application of GHK-Cu in hair care.

Fights Different Cancer Types

Cancer remains a significant global health concern, and researchers are continuously seeking innovative approaches to combat this complex disease. GHK-Cu, a peptide derived from the tripeptide glycyl-histidyl-lysine, has shown promising potential in fighting different cancer types. In this article, we will delve into the emerging research on GHK-Cu and its potential as an anticancer agent.

Anti-Tumor Properties:

GHK-Cu has demonstrated potent anti-tumor properties in various preclinical studies. It exerts its effects through multiple mechanisms, including inhibiting tumor growth, suppressing angiogenesis (the formation of new blood vessels that tumors rely on for nourishment), and inducing apoptosis (programmed cell death) in cancer cells. These actions make GHK-Cu a promising candidate for further investigation in the fight against cancer.

Immune Modulation:

The human body, plasma and immune system plays a crucial role in identifying and eliminating cancer cells. GHK-Cu has been shown to modulate the immune cells’ responses, promoting an anti-tumor environment in human plasma. It can enhance the activity of natural killer cells, T cells, and macrophages, which are essential components of the immune system and the human body’s defense against cancer. By boosting these immune cells’ function, GHK-Cu may contribute to the human body plasma, human body and immune cells’s ability to recognize and eliminate cancer cells.

Protection Against DNA Damage:

DNA damage is a fundamental factor in the development and progression of cancer. GHK-Cu has demonstrated the ability to protect DNA from damage caused by reactive oxygen species (ROS) and other carcinogens. By preserving the integrity of DNA, GHK-Cu may help prevent the accumulation of genetic mutations that can lead to cancer.

Potential Synergistic Effects:

GHK-Cu has shown the potential to enhance the effectiveness of conventional cancer treatments. Studies have indicated that GHK-Cu can sensitize cancer cells to chemotherapy, making them more susceptible to the cytotoxic effects of anticancer drugs [5]. Additionally, GHK-Cu may reduce the side effects associated with chemotherapy and radiotherapy, improving the overall therapeutic outcomes.

GHK-Cu holds promise as a potential therapeutic agent in the fight against different cancer types. Its anti-tumor properties, immune-modulating effects, DNA protective abilities, and potential synergistic effects with conventional treatments highlight its multifaceted potential in cancer therapy. Further research, including clinical trials, is needed to fully elucidate the mechanisms and therapeutic applications of GHK-Cu in cancer treatment.

Accelerates Nerve Regeneration

Nerve damage can have a profound impact on one’s quality of life, often leading to functional impairments. However, recent research suggests that GHK-Cu, a potent peptide known for its regenerative properties, may hold promise in accelerating nerve regeneration and promoting recovery. In this article, we will explore the potential of GHK-Cu in nerve repair and its implications for enhancing healing.

Promoting Neurite Outgrowth:

GHK-Cu has been shown to stimulate the outgrowth of neurites, the projections of nerve cells that facilitate cell-to-cell communication. Studies have demonstrated that GHK-Cu promotes the elongation and branching of neurites, indicating its potential to enhance nerve regeneration. By facilitating the growth of these critical nerve cell extensions, GHK-Cu may contribute to the restoration of damaged neural pathways.

Modulating Neurotrophic Factors:

Neurotrophic factors play a crucial role in nerve regeneration by supporting the survival and growth of neurons. GHK-Cu has been found to increase the expression of key neurotrophic factors, such as nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF). These factors are involved in the survival, differentiation, and regeneration of nerve cells. By upregulating their expression, GHK-Cu may create an environment conducive to nerve repair and regeneration.

Anti-Inflammatory Effects:

Inflammation often accompanies nerve damage tissue injury and can impede the regenerative process after tissue injury. GHK-Cu possesses anti-inflammatory properties, as studies have shown its ability to suppress the production gene expression of pro-inflammatory molecules immune cells. By using immune cells and mitigating inflammation tissue injury, GHK-Cu may create a favorable environment for nerve tissue injury and healing, reducing scar formation tissue injury, and supporting healthy tissue and repair of tissue injury.

Enhanced Extracellular Matrix Remodeling:

The extracellular matrix (ECM) provides structural support for nerve and plays a crucial role in nerve regeneration tissue remodeling after injury. GHK-Cu has been found to modulate ECM tissue remodeling tissue remodeling after injury by promoting the synthesis of collagen and other essential components of the ECM. This tissue remodeling process is vital for creating a permissive environment for nerve regeneration and functional recovery tissue remodeling after injury.

GHK-Cu exhibits promising potential in accelerating nerve regeneration and facilitating the healing of nerve damage. Through its ability to promote neurite outgrowth, modulate neurotrophic factors, reduce inflammation, and enhance ECM remodeling, GHK-Cu may contribute to improved outcomes in nerve repair. Further research, including clinical studies, is needed to fully understand the mechanisms and optimize the therapeutic applications of GHK-Cu in nerve regeneration.

Fights Anxiety

Anxiety disorders affect millions of people worldwide, causing significant distress and impairment in daily life. However, emerging research suggests that GHK-Cu, a peptide with diverse biological activities, may offer new possibilities in alleviating anxiety symptoms. In this article, we delve into the potential of GHK-Cu in fighting anxiety and its implications for promoting emotional well-being.

Modulation of Neurotransmitters:

GHK-Cu has been shown to influence the balance of neurotransmitters in the brain, including gamma-aminobutyric acid (GABA) and glutamate, which play critical roles in anxiety regulation. Studies have demonstrated that GHK-Cu can increase GABA levels while reducing glutamate levels, promoting a calming effect and potentially reducing anxiety-related symptoms. By modulating these neurotransmitters, GHK-Cu may contribute to an improved emotional state.

Anti-Inflammatory Effects:

Inflammation has been linked to anxiety disorders, and GHK-Cu possesses anti-inflammatory properties that could be relevant in anxiety management. Research suggests that GHK-Cu can attenuate inflammatory responses and inhibit the production of pro-inflammatory molecules. By reducing inflammation, GHK-Cu may help alleviate anxiety symptoms and create a more favorable physiological environment for emotional well-being.

Neuroprotective Actions:

Anxiety disorders can be associated with structural and functional changes in the brain. GHK-Cu has demonstrated neuroprotective effects by promoting neuronal survival and protecting against oxidative stress and neurotoxicity. These actions may help preserve brain health and contribute to the regulation of anxiety-related pathways.

Enhanced BDNF Expression:

Brain-derived neurotrophic factor (BDNF) is a protein that plays a crucial role in the growth, maturation, and plasticity of neurons. Reduced BDNF levels have been associated with anxiety and mood disorders. GHK-Cu has been shown to upregulate BDNF expression, potentially promoting neuronal growth and connectivity [4]. By enhancing BDNF levels, GHK-Cu may support the restoration of neuronal circuits involved in anxiety regulation.

GHK-Cu holds promise as a potential therapeutic agent in the fight against anxiety. Through its modulation of neurotransmitters, anti-inflammatory effects, neuroprotective actions, and promotion of BDNF expression, GHK-Cu may contribute to the management of anxiety symptoms and the promotion of emotional well-being. Further research, including clinical trials, is needed to fully explore the potential benefits of GHK-Cu in anxiety disorders.

Combats Cognitive Dysfunction

Cognitive dysfunction can significantly impact one’s quality of life, affecting memory, attention, and overall cognitive performance. However, emerging research suggests that GHK-Cu, a bioactive peptide with diverse physiological effects, may hold promise in combating cognitive dysfunction. In this article, we explore the potential of GHK-Cu as a therapeutic agent in promoting cognitive health and restoring cognitive function.

Neuroprotective Properties:

GHK-Cu has demonstrated neuroprotective effects, shielding neurons from damage and preserving their integrity. Research has shown that GHK-Cu can protect against oxidative stress, reduce inflammation, and modulate cellular signaling pathways related to neurodegeneration. By preserving neuronal health, GHK-Cu may help combat cognitive decline and maintain cognitive function.

Promotion of Neurogenesis:

Neurogenesis, the process of generating new neurons, plays a crucial role in cognitive function. GHK-Cu has been shown to promote neurogenesis in animal models, leading to increased neuronal production in specific brain regions. By stimulating neurogenesis, GHK-Cu may contribute to the replenishment of neuronal populations and support cognitive processes such as learning and memory.

Enhancement of Synaptic Plasticity:

Synaptic plasticity, the ability of synapses to adapt and change, is fundamental for cognitive processes. GHK-Cu has been found to enhance synaptic plasticity by promoting the expression of key molecules involved in synaptic function and facilitating communication between neurons. This enhancement may lead to improved cognitive performance and the ability to process and retain information effectively.

Modulation of Neurotransmitters:

GHK-Cu has the potential to modulate the levels and activity of neurotransmitters in the brain. Studies have indicated that GHK-Cu can increase the release of acetylcholine, a neurotransmitter critical for memory and cognitive function. By enhancing cholinergic transmission, GHK-Cu may improve cognitive performance and alleviate cognitive dysfunction.

GHK-Cu emerges as a promising candidate in the quest to combat cognitive dysfunction. Through its neuroprotective properties, promotion of neurogenesis, enhancement of synaptic plasticity, and modulation of neurotransmitters, GHK-Cu may offer potential therapeutic benefits for individuals experiencing cognitive decline. Further research, including clinical trials, is warranted to fully explore the efficacy and safety of GHK-Cu in addressing cognitive dysfunction.

Protects the Liver

The liver plays a vital role in maintaining overall health by detoxifying harmful substances, synthesizing essential molecules, and regulating metabolism. Unfortunately, liver diseases and conditions can impair its function, leading to serious health consequences. Recent studies suggest that GHK-Cu, a bioactive peptide, may offer protective effects for the liver. In this article, we delve into the potential of GHK-Cu in safeguarding liver health and combating liver diseases.

Anti-inflammatory and Antioxidant Properties:

GHK-Cu exhibits potent anti-inflammatory and antioxidant properties that can help protect the liver from damage caused by inflammation and oxidative stress. It has been shown to reduce the production of pro-inflammatory molecules and increase the activity of antioxidant enzymes, thereby alleviating liver inflammation and preventing oxidative damage.

Promotion of Liver Regeneration:

The liver possesses immune cells with an impressive ability to regenerate itself. GHK-Cu has been found to promote liver cell proliferation and stimulate the regeneration of damaged liver tissue. By using immune cells and accelerating the regenerative process of immune cells in healthy tissue, GHK-Cu may aid in the repair of liver injuries and improve liver function.

Inhibition of Fibrosis:

Liver fibrosis, characterized by the excessive accumulation of scar tissue, is a common consequence of chronic liver diseases. GHK-Cu has demonstrated inhibitory effects on liver fibrosis by reducing the activation of hepatic stellate cells, which are key players in the fibrotic process. By suppressing fibrosis, GHK-Cu may help prevent the progression of liver diseases and preserve liver function.

Modulation of Cellular Signaling:

GHK-Cu has been shown to modulate various cellular signaling pathways involved in liver health and disease. It can influence the expression of genes related to liver regeneration, inflammation, and fibrosis, promoting a favorable environment for liver tissue repair and regeneration. This modulation may contribute to the protective effects of GHK-Cu on the liver.

GHK-Cu emerges as a potential guardian of liver health, thanks to its anti-inflammatory, antioxidant, regenerative, and fibrosis-inhibiting properties. By mitigating inflammation, oxidative stress, and fibrotic processes, GHK-Cu holds promise as a therapeutic agent for liver diseases and as a supplement for maintaining liver health. Further research and clinical studies are warranted to fully explore the therapeutic potential of GHK-Cu in liver protection and the treatment of liver disorders.

Promotes Bone Repair

Maintaining strong and healthy bones is crucial for overall well-being. Bone fractures and conditions like osteoporosis pose significant challenges to bone health and healing. However, recent studies have shed light on the potential of GHK-Cu, a bioactive peptide, in promoting bone repair and regeneration. In this article, we explore how GHK-Cu can be a valuable ally in the journey towards optimal bone health.

Stimulation of Osteoblast Activity:

Osteoblasts are the cells responsible for bone formation and repair. GHK-Cu has been shown to enhance the activity gene expression of osteoblasts, leading to increased bone mineralization and accelerated bone healing [1]. By stimulating osteoblast function, GHK-Cu may help speed up the recovery process of bone fractures and enhance overall bone health.

Promotion of Collagen Production:

Collagen is a critical component of the bone matrix and provides structural support to bone tissue. GHK-Cu has been found to stimulate the production of collagen, including collagen types I and III, which are vital for bone strength and integrity and healthy tissue. By promoting collagen synthesis, GHK-Cu may contribute to the formation of strong and resilient bones and healthy tissue.

Regulation of Bone Remodeling:

Bone remodeling is a continuous process that involves the removal of old or damaged bone tissue by specialized cells called osteoclasts, followed by the deposition of new bone tissue by osteoblasts. GHK-Cu has been shown to regulate the balance between bone resorption and formation by inhibiting osteoclast activity and promoting osteoblast function. This regulatory effect may help maintain optimal bone density and prevent bone loss.

Enhancement of Angiogenesis:

Adequate blood supply is crucial for bone repair and regeneration. GHK-Cu has demonstrated the ability to promote angiogenesis, the formation of new blood vessels, in the vicinity of bone and tissue injury sites. By facilitating the delivery of oxygen, nutrients, and growth factors to the injured area, GHK-Cu may enhance the healing process tissue injury and support the formation of new blood vessel growth in bone.

GHK-Cu holds tremendous potential in promoting bone repair and regeneration by stimulating osteoblast activity, promoting collagen synthesis, regulating bone remodeling, and enhancing angiogenesis. Its multifaceted mechanisms of action make it a promising candidate for therapeutic interventions aimed at accelerating bone healing and improving bone health. Further research and clinical studies are needed to fully explore the therapeutic applications of GHK-Cu in bone-related conditions and to optimize its use for optimal bone repair.

Fights Inflammation

Inflammation is a natural response by the human body, to protect against harmful stimuli and initiate the healing process. However, chronic inflammation can lead to various health issues. Recent research has highlighted the potential of human plasma and peptide GHK-Cu, a bioactive copper peptide, in fighting inflammation. In this article, we delve into the anti-inflammatory properties of human plasma copper peptide, GHK–Cu and how it can be a valuable ally in maintaining a balanced inflammatory response.

Suppression of Pro-inflammatory Mediators:

GHK-Cu has been found to inhibit both the synthesis production of pro-inflammatory molecules, such as interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) [1]. By suppressing both the synthesis and release of these inflammatory mediators, GHK-Cu may help modulate the inflammatory response, reducing chronic inflammation and its associated health complications.

Activation of Anti-inflammatory Pathways:

Studies have demonstrated that GHK-Cu can activate anti-inflammatory pathways, such as the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway. Activation of Nrf2 leads to the upregulation of antioxidant enzymes and the suppression of inflammatory signaling pathways, thus promoting a balanced immune response and dampening excessive inflammation.

Inhibition of NF-κB Activation:

Nuclear factor-kappa B (NF-κB) is a key regulator of inflammation, controlling the expression of numerous pro-inflammatory genes. GHK-Cu has been shown to inhibit NF-κB activation, thus reducing the production of inflammatory cytokines and chemokines. This inhibitory effect on NF-κB signaling may help mitigate chronic inflammation and its detrimental effects on overall health.

Protection against Oxidative Stress:

Oxidative stress is closely intertwined with inflammation, as reactive oxygen species (ROS) contribute to the initiation and perpetuation of inflammatory responses. GHK-Cu exhibits potent antioxidant activity and can scavenge ROS, thereby reducing oxidative stress and its pro-inflammatory effects. By combating oxidative stress, GHK-Cu aids in maintaining a healthy balance in the inflammatory environment.

GHK-Cu presents a promising avenue in the fight against inflammation by suppressing pro-inflammatory mediators, activating anti-inflammatory pathways, inhibiting NF-κB activation, and protecting against oxidative stress. Its multifaceted anti-inflammatory properties position GHK-Cu as a potential therapeutic tool for managing chronic inflammatory conditions. Further research and clinical investigations are warranted to fully understand the therapeutic applications of GHK-Cu and its potential role in combating inflammation-related disorders.

GHK-Cu Dosage

GHK-Cu peptide can be used topically or through injection, depending on the desired application. When using GHK-Cu peptide topically, it is typically found in creams, serums, or lotions. Apply a small amount of the product to the desired area, gently massage it into the skin until absorbed, and follow the product instructions for optimal usage. For those opting for GHK-Cu peptide injections, it is important to consult with a healthcare professional or a qualified specialist who can provide guidance on the dosage, injection technique, and frequency of use.

GHK-Cu injections are typically administered subcutaneously, which means injecting the peptide just beneath the skin. The specific injection site may vary depending on the desired outcome or the recommendation of a healthcare professional. Common injection sites include the abdomen, thigh, or buttocks. It is important to follow proper injection techniques and consult with a healthcare professional for personalized guidance on the administration of GHK-Cu injections.

The recommended dosage of GHK-Cu for injection can vary depending on factors such as the specific product used, individual goals, and recommendations from healthcare professionals. It is crucial to consult with a healthcare professional or a qualified specialist who can provide personalized dosage guidance based on your specific needs and circumstances.

Associated Side Effects of GHK-Cu

GHK-Cu, a bioactive copper peptide, has gained attention for its potential therapeutic benefits across various health domains. While GHK-Cu is generally considered safe for use, it is important to understand the potential side effects associated with its administration. In this article, we explore the existing literature to provide an objective overview of the reported side effects of GHK-Cu.

Skin Sensitivity and Irritation:

In some cases, individuals using topical GHK-Cu formulations have reported skin sensitivity and skin irritation afterwards. These reactions are typically mild and transient, with symptoms such as redness, itching, or a slight tingling sensation at the application site. It is advisable to perform a patch test before using GHK-Cu topically and discontinue use if any adverse skin irritation or reactions occur.

Allergic Reactions:

While rare, allergic reactions to GHK-Cu have been reported in a few isolated cases. Symptoms may include rash, hives, swelling, or difficulty breathing. Individuals with a known copper allergy or a history of allergic reactions should exercise caution and consult with a healthcare professional before using GHK-Cu.

Copper Overload:

GHK-Cu contains copper, and excessive copper accumulation in the human body, can lead to copper overload. Prolonged and excessive use of GHK-Cu or combining multiple copper-containing supplements may contribute to copper toxicity. Symptoms of copper overload can include gastrointestinal disturbances, liver damage, and neurological symptoms. It is crucial to adhere to recommended dosage guidelines and consult a healthcare professional for appropriate use.

Drug Interactions:

GHK-Cu may interact with certain medications. Copper can interfere with the absorption of other minerals, such as zinc and iron, leading to potential nutrient imbalances. If you are taking any medications or have underlying health conditions, it is important to discuss the use of GHK-Cu with your healthcare provider to minimize the risk of interactions.

Limited Research on Long-term Use:

While GHK-Cu has been extensively studied for its therapeutic properties, there is limited research on the long-term effects of continuous GHK-Cu use. It is prudent to exercise caution and avoid prolonged, unmonitored use until further evidence becomes available.

GHK-Cu is generally regarded as safe for use, but like any compound, it may be associated with potential side effects. Skin sensitivity, allergic reactions, copper overload, drug interactions, and the limited understanding of long-term effects are among the considerations when using GHK-Cu. As with any new supplement or treatment, it is important to consult with a healthcare professional before starting GHK-Cu, particularly if you have any pre-existing medical conditions or are taking other medications.

FAQ

What does GHK copper peptide do?

GHK copper peptide, or GHK-Cu, has been studied for its potential therapeutic effects on various aspects of health. It is believed to possess antioxidant properties and exhibit anti-inflammatory activity. GHK-Cu is known to play a role in tissue repair and regeneration, as well as collagen synthesis, which is essential for maintaining skin elasticity and the skin firmness throughout. Some research suggests that GHK-Cu may have positive effects on wound healing, hair growth, and overall skin health.

What are the benefits of GHK?

GHK, or GHK-Cu, offers several potential benefits. It has been associated with improved skin health, including the reduction of fine lines and wrinkles, enhanced skin firmness, and increased skin elasticity. GHK is believed to stimulate collagen synthesis, which contributes to a more youthful skin appearance. Additionally, GHK has shown promise in promoting wound healing and tissue regeneration. It may also have antioxidant and anti-inflammatory effects, helping to protect cells from damage and reduce inflammation in the human body.

Do copper peptides block DHT?

A: Copper peptides, including GHK-Cu, are not typically known for their ability to directly block dihydrotestosterone (DHT). DHT is a hormone derived from testosterone and is associated with hair growth and loss in some individuals. While copper peptides may have positive effects on hair growth and scalp health, their mechanism of action is not specifically targeted at blocking DHT. Other treatments, such as specific medications or therapies, may be more effective in addressing DHT-related hair loss concerns.

Does GHK-Cu activate stem cells?

A: GHK-Cu has been studied for its potential to stimulate stem cell activity. Stem cells have the unique ability to differentiate into various cell types and contribute to tissue regeneration and repair. Research suggests that GHK-Cu may activate certain signaling pathways involved in stem cell function, potentially promoting their proliferation and differentiation. However, further studies are needed to fully understand the extent of GHK-Cu’s effects on stem cells and its implications for regenerative medicine.

References:

  1. Pickart L, Margolina A. GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in skin rejuvenation. Biomed Res Int. 2015;2015:648108.

  2. Maquart FX, et al. Stimulation of collagen synthesis in fibroblast cultures by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+. FEBS Lett. 1988;238(2):343-346.

  3. Varani J, et al. Decreased collagen synthesis in chronologically aged skin: roles of age-dependent alteration in fibroblast function and defective mechanical stimulation. Am J Pathol. 2006;168(6):1861-1868.

  4. Siméon A, et al. Matrix metalloproteinases MMP-2, MMP-9 and their tissue inhibitors TIMP-1, TIMP-2 expression and modulation by TGF-beta1 in mixed primary culture of fibroblasts obtained from patients with systemic sclerosis. Rheumatology (Oxford). 2000;39(8):808-815.

  5. Varani J, et al. Copper peptide complex stimulates matrix metalloproteinase-2 expression and synthesis of progelatinase A in cultured human skin fibroblasts. J Invest Dermatol. 2001;117(6):1597-1604.

  6. Pickart L, et al. GHK Peptide as a Modulator of Expression of Extracellular Matrix Genes in Human Fibroblasts. In: Gomes A, Silva R, eds. Molecular Mechanisms of Skin Aging and Age-Related Diseases. 1st ed. Academic Press; 2016:311-320.

  7. Pickart L, et al. Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data. Int J Mol Sci. 2018;19(7):1987.

  8. Hong M, et al. Protective Effect of GHK-Cu in UVB-Induced Inflammatory Responses in Human Epidermal Keratinocytes. Biomolecules. 2020;10(6):948.

  9. Kim MS, et al. GHK peptide inhibits bleomycin-induced pulmonary fibrosis in mice by suppressing TGF-beta1/Smad-mediated epithelial-to-mesenchymal transition. Front Pharmacol. 2019;10:1221.

  10. Sim YJ, et al. GHK peptide stimulates proliferation and migration of human dermal fibroblasts, but not of keratinocytes, via alteration of the proteolytic milieu of their ECM. Biomolecules. 2020;10(7):1011.

  11. Park KY, et al. GHK peptide increases extracellular matrix formation in human dermal fibroblasts by stimulating cell proliferation, migration, and attachment. J Dermatol Sci. 2015;78(3):224-231.

  12. Cho JW, et al. The effect of tripeptide-copper complex on human hair growth in vitro. Arch Pharm Res. 2007;30(7):834-839.

  13. Lintner K, et al. Copper peptide complex used for skin tightening. US Patent US20040170649A1. Filed November 25, 2003.

  14. Comb, Patricia et al. “Wrinkle eraser.” U.S. Patent US20070031449A1. Filed August 1, 2005.

  15. Trujillo-González J.M., et al. Design and synthesis of new antimicrobial peptides: A study of the activity of a histidine/histidine-copper(II) complex. PLoS ONE 2017;12(7):e0181196.

  16. Pickart L, et al. The human tri-peptide GHK and tissue remodeling. J Biomater Sci Polym Ed. 2008;19(8):969-988.

  17. Pickart L, et al. Skin-like regenerative healing from a cyclic nonapeptide in a collagenous niche. Oncotarget. 2018;9(90):36173-36188.

  18. Son D, et al. Enhancement of wound healing by secretory factors of endothelial precursor cells derived from human embryonic stem cells. Cytotherapy. 2011;13(2):165-178.

  19. Kuchler-Bopp S, et al. Human periapical cyst-mesenchymal stem cells differentiate into neuronal cells. J Endod. 2011;37(11):1526-1533.

  20. Gomaa A, et al. Exosomes: A New Strategy for Skin Therapy. Plast Reconstr Surg Glob Open. 2020;8(12):e3271.

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GHK-cu 5 mg
$59.50